In vivo and in vitro studies on the early embryonic lethal tail-short (Ts) in the mouse

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Abstract
An histological study reveals that embryos homozygous for the mutation tail‐short (Ts) become abnormal as morulae, although a small amount of cell division may continue to take place during the following day. Homozygotes can be identified at 3½ days post coitum (p.c.) by several criteria including low cell number, absence of cavitation, and weak cytoplasmic staining with haematoxylin. A similar pattern of developmental arrest is exhibited during culture, although an initial degreeof cavitation occurs more frequently.