Effects of Liposome-Entrapped Doxorubicin on Liver Metastases of Mouse Colon Carcinomas 26 and 382

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Abstract
The effects of doxorubicin (DOX) and DOX entrapped in standardized liposomes [mean diameter, 0.15 μm; (DOX-Lip)] on the survival of mice bearing liver metastases of mouse colon carcinoma CT38LD (C57BL/6J mice) or CT26 (BALB/c mice) were investigated. In vitro cultured CT38LD cells were more sensitive to DOX than CT26. In vivo DOX and DOX-Lip, administered iv 10 mg/kg weekly to a maximum of five injections, increased the life-spans of mice bearing CT38LD liver metastases 32% (P<.05) and 64% (P<.05), respectively. DOX-Lip was more effective than DOX in prolonging survival (P<.05). Free DOX did not significantly increase the life-spans of mice bearing CT26 liver metastases (P>.5), whereas DOX-Lip increased the life-spans 35% (P<.05). The results suggest that liposomal delivery of agents to the liver can enhance therapeutic activity and could be used as an arm of protocols for adjuvant therapy of liver metastases.