The Reliability of the L. E. Test

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Abstract
IN JANUARY, 1948, Hargraves, Richmond and Morton1 announced the discovery of a cell in bone-marrow preparations from patients with disseminated lupus erythematosus that they called the L. E. cell. It was soon demonstrated that the factor producing this phenomenon was in the plasma.2 3 4 When plasma from patients with disseminated lupus erythematosus is added to normal bone marrow the L. E. cell appears. Further studies identified gamma globulin as the fraction of the plasma responsible for this phenomenon.5 From these experiments the L. E. plasma test evolved and has been widely used in the diagnosis of systemic lupus erythematosus.If the . . .