Preferred Orientation of Crystalline Particles within Tablets. III. Change in Degree of Preferred Orientation of Aspirin Crystals during Compression

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Abstract
The degree of preferred orientation of aspirin crystals in a tablet as a function of compression force was measured using the X-ray diffraction method. Preferred orientation took place during compression and the degree was affected by the size and morphology of the crystals. Thin, plate-like crystals had the strong tendency to orient preferentially at an early stage of compression, while pulverized crystals oriented gradually at over 100 kg/cm2 of the compression force. Volume, specific surface area, pore size distribution and breaking strength of the tablets were measured and the relationship among these factors was investigated.

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