The Influence of Locally Administered Prostaglandin E2 and F2α on Uterine Motility in the Intact Non‐Pregnant Human Uterus

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Abstract
Clinical studies on the effect of locally administered prostaglandin [PG] E2 and F2.alpha. on the sensitivity and reactivity of the non-pregnant human uterus were performed in 16 volunteers. With the use of the flaccid microballoon technique, uterine recordings were made at frequent intervals throughout the menstrual cycle. As little as 0.25 .mu.g PGE2 or 1.0 .mu.g PGF2.alpha. effected an increase in uterine motility during most of the proliferative and secretory phases of the menstrual cycle. A marked decrease in sensitivity and suppression of reactivity to either PG compound was observed around ovulation. An inhibition of uterine contractility in response to PGE2 but not to PGF2.alpha. was noted during active menstrual bleeding. Circulating levels of estrogen could be correlated generally with these uterine responses. Endogenous PG normally occur in the secretory endometrium in levels compatible with the amount of exogenously administered PG which elicited increased, decreased or unchanged uterine activity. Local PGE2 and F2.alpha. in concert with variable levels of circulating estrogen apparently may play important roles in the cyclic regulation of uterine motility during the menstrual cycle.