The fate of Ticlopidine in the organism II. — Distribution and elimination of Ticlopidine14C after a single oral administration in the rat
- 1 July 1979
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 4 (3) , 133-138
- https://doi.org/10.1007/bf03189415
Abstract
Summary In the Rat, distribution and elimination of Ticlopidine C14 after a single oral dose of 25 mg/kg were studied and compared with that observed after a single intravenous injection of the same dose. The plasma decreases of total radioactivity were found to be identical regardless of administration route, indicating almost complete absorption of the labelled molecule. The elimination half-life, which was 1.56 ± 0.08 days, was equivalent to the half-life measured after intravenous injection, and no difference in tissues distribution was observed. As in the case of intravenous injection, the radioactivity was eliminated principally in the feces and only to a slight degree in the urine.Keywords
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- The fate of ticlopidine in the organism I: Distribution and elimination of Ticlopidine14C after a single intravenous injection in the ratEuropean Journal of Drug Metabolism and Pharmacokinetics, 1978