THE EFFECT OF ORALLY ADMINISTERED GESTAGEN ON THE ANAPHYLACTIC REACTIONS IN RATS

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Abstract
SUMMARY: The effect of a gestagen (lynoestrenol) on anaphylactic reactions was investigated in rats and the effect of intracutaneous and intravenous re-injection of horse serum used as antigen was examined. Gestagen treatment intensified the cutaneous reaction, decreased the rectal temperature and caused death in 50 % of the animals. In control rats the intravenous re-injection of the antigen only caused a slight decrease in rectal temperature without killing any of them. It is suggested that the markedly increased sensitivity of rats, a species normally resistant to anaphylactic reactions, may be due to the inhibitory effect of the administered gestagen on pituitary gonadotrophin secretion.

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