The influence of drugs on the kinin-forming system in relation to pregnancy and parturition in the rat

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Abstract
The duration of normal gestation and parturition in the rat can be changed by treatment with drugs which alter the equilibrium of the kallikrein-kinin system. The kallikrein inhibitor, aprotinin, when given from days 19-22 of pregnancy prolongs gestation. Treatment with aprotinin from days 20-22 of pregnancy prolongs the parturient process, as does a single dose given on the morning of day 22. Kallikrein, when administered from days 19-22 of pregnancy, prolongs gestation and abolishes the pre-parturient behavior (labor). Parturition is prolonged, and many fetuses are stillborn. Soybean trypsin inhibitor when given from days 19-22 of pregnancy delays and prolongs parturition; maternal hemorrhage occurs during birth, and many fetuses are born dead or are abandoned at birth. The kallikrein-kinin system probably plays a functional role in the normal process of parturition in the rat.

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