Adenylate Kinase Isoenzyme Patterns in Normal and Neoplastic Human Lung, and in Various Adult as Compared to Fetal Rat Tissues

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Abstract
The isozyme pattern and total activity of adenylate kinase were studied in normal adult and fetal human and rat tissues using starch gel electrophoresis. Three adenylate kinase isoenzymes were identified in human tissues. Although normal adult lung exhibited higher adenylate kinase activity than did its fetal or neoplastic variant, isozyme patterns in the 3 types of tissues were indistinguishable from each other and from that in fetal human liver. The pattern of these 3 isozymes in rat lung (as in spleen) also did not change between fetal and adult life. Adult kidney and heart of this species did appear to contain isozymes not present in fetal life. Brain (adult and fetal) was strikingly different from all the other tissues in that it contained only 1 adenylate kinase isozyme. The total adenylate kinase activity/g of adult rat liver, kidney and lung was significantly higher than in the cognate fetal organs; that in brain or spleen did not change with age. The activity in adult heart (similar to the fetal one) was higher than in any other tissue examined.