Prophylactic and Other Treatment for "Histaminic," "Cluster," or "Limited" Variant of Migraine

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Abstract
A comparison was made between the main therapeutic measures advocated for this well-defined clinical syndrome. The methods compared in 52 patients were sphenopalatine ganglion anesthesia, histamine desensitization, and prophylactic ergotamine tartrate. The efficacy of the first two methods was shown to be equally doubtful, in particular because each attack and each cycle of headaches are self-limiting. Ergotamine tartrate, while ineffective during the attack, provided excellent prophylaxis for the duration of the cycle. The required dosage exceeded the conventional margin of safety for this drug yet did not produce any toxic effects. The results with massive oral prevention were equal to those obtained parenterally. "Limited migraine variant" or "hemicrania limitata" seem the most descriptive, comprehensive, and internationally acceptable terms for this many-named condition.

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