Proinsulin‐like material in mouse foetal brain cell cultures
- 26 March 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 168 (2) , 299-302
- https://doi.org/10.1016/0014-5793(84)80266-5
Abstract
Two main forms of immunoreactive insulin have been identified in cultures of foetal mouse brain using HPLC and gel filtration. The major component which resembled proinsulin was converted by trypsin to the minor form which was similar to authentic pancreatic insulin in chromatographic behaviour. Both components showed immunological properties comparable to insulin and proinsulin including sensitivity of the former to reduction and alkylation.Keywords
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