Primary Infection by Epstein–Barr Virus Presenting as Aplastic Anemia

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Abstract
To the Editor: Aplastic anemia occasionally follows infectious mononucleosis.1 , 2 We have observed a case of aplastic anemia occurring simultaneously with clinically inapparent primary infection with Epstein–Barr virus (EBV), the etiologic agent of infectious mononucleosis.A previously healthy 12-year-old girl had bruising and epistaxis a week after a brief episode of sore throat. The initial physical and laboratory evaluation revealed only bruises, petechiae, and thrombocytopenia; a bone-marrow aspiration showed severe generalized depletion. Hematopoiesis became irreversibly absent within two weeks, and marrow-biopsy specimens showed no hematopoietic precursors, confirming the diagnosis of aplastic anemia by strict criteria.1 A suitable marrow-transplant donor could not . . .

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