GLUTAMIC OXALACETIC TRANSAMINASE IN CEREBROSPINAL FLUID

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Abstract
The control value of glutamic oxalacetic transaminase of the spinal fluid among 30 subjects was 16.8 [plus or minus] 7.6 units. A significant elevation of spinal fluid GOT in acute cerebro-vascular accidents was noted in 9 out of 32 tested patients, comprising 28% of the total. In patients with acute cerebrovascular accidents high spinal fluid GOT levels tend to indicate poor prognosis and low GOT levels a favorable prognosis. The spinal fluid GOT in patients with brain tumors was normal except in those with obstructive hydrocephalus. In one case of congenital internal hydrocephalus there was marked elevation. The convulsive disorders showed elevated spinal fluid GOT only when the specimens were taken during or soon after the end of the convulsion. The spinal fluid GOT was normal in the other neurologic diseases included in this series. Transaminase levels in one human brain was highest in the cerebellum, followed by the pons, cerebral cortex and white matter, hypothalamus and thalamus, in that order.

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