Characterization of a newly discovered T-cell receptor β-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment
- 1 August 2000
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 6 (8) , 904-909
- https://doi.org/10.1038/78667
Abstract
The facilitating cell is a rare CD8+ bone marrow subpopulation that can enhance allogeneic hematopoietic stem cell engraftment across complete major histocompatibility complex barriers without inducing acute graft-versus-host disease. Here we describe a CD3epsilon-associated complex on the facilitating cell surface that consists of the T-cell receptor beta-chain disulfide-linked to a previously unknown 33-kilodalton glycoprotein. Provisionally called FCp33, this glycoprotein does not represent any of the known protein chains or surrogates associated with CD3-T-cell receptor beta. Expression of this CD3-T-cell receptor beta-FCp33 complex directly correlates with the facilitating cell's functional ability to enhance allogeneic stem cell engraftment in vivo.Keywords
This publication has 33 references indexed in Scilit:
- Subunit Composition of Pre–T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3δ Is Physically Associated but Not Functionally RequiredThe Journal of Experimental Medicine, 1997
- STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTORAnnual Review of Immunology, 1997
- Inhibition by CsA and FK506 of the in vitro proliferative response of γδ T cells on stimulation with anti-TCR δ monoclonal antibodyTransplant Immunology, 1996
- T cell receptor β chain dimers on immature thymocytes from normal miceEuropean Journal of Immunology, 1993
- Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR TransgenesScience, 1993
- RAG-1-deficient mice have no mature B and T lymphocytesCell, 1992
- Surface expression of CD3 in the absence of T cell receptor (TcR): evidence for sorting of partial TcR/CD3 complexes in a post-endoplasmic reticulum compartmentEuropean Journal of Immunology, 1989
- Identification of the components of the murine T cell antigen receptor complexCell, 1985
- High resolution two-dimensional electrophoresis of basic as well as acidic proteinsCell, 1977
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970