Effect of Thyroxine on Permeability of the Neonatal Rat Lung to Drugs

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Abstract
The effect of thyroxine (1–2 μg/g i.p. on days 1–4 after birth) on development of adult-type permeability characteristics in the lung was investigated in rats 6–18 days of age. In both treated and control rats, the lipid-soluble drug procaine amide was absorbed at similar rates in all age groups. In contrast, in thyroxine-treated animals, pulmonary’ absorption rates for the lipid-insoluble compounds mannitol and p-aminohippuric acid declined to adult levels at age 6–12 days, 6 days earlier than in controls. Thyroxine treatment thus accelerates development of adult permeability characteristics in the pulmonary epithelium.

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