Use of "Granuloma Pouch" Technic in the Study of Antiphlogistic Corticoids

Publisher Website
Google Scholar
Abstract
Using the "granuloma pouch" technic, it was possible to produce very large amts. of inflammatory tissue and fluid (corresponding, in some cases, to as much as 25% of total body wt.) in the rat, without interfering with the general well-being of the animal. Introduction of small amts. of hydrocortisone, directly into the wall of the pouch, completely prevents development of these inflammatory structures. Introduction of the same amt. of hydrocortisone into the lumen of the pouch, or into connective tissue at a distance of only about 1 mm. from the pouch, is virtually ineffective. Croton oil used to produce these granuloma pouches retained part of its irritating effects, even after a sojourn of 14 days, in hydrocortisone protected connective tissue. Although here it failed to cause inflammation, it still produced considerable damage, with hemorrhagic necrosis, when introduced into the unprotected connective tissue of other recipient animals.

This publication has 1 reference indexed in Scilit: