MICROBIAL TRANSFORMATIONS OF NATURAL ANTITUMOR AGENTS .4. FORMATION OF N-(2)-NOR-D-TETRANDRINE BY CUNNINGHAMELLA-BLAKESLEEANA (ATCC 8688A)
- 1 January 1977
- journal article
- research article
- Vol. 40 (3) , 239-246
Abstract
Microbial transformation experiments were conducted with the antitumor alkaloid, d-tetrandrine. The alkaloid is selectively demethylated at the N-(2)-position by C. blakesleeana ATCC 8688a. The biotransformation reaction is highly selective and uncomplicated by side-product formation. N-demethylation of the alkaloid using methylchloroformate is not regio-specific. Procedures used in screening microorganisms for their abilities to yield metabolites of d-tetrandrine are evaluated.This publication has 4 references indexed in Scilit:
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