Hyaline Membrane Disease in Twins

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Abstract
In analyzing the evidence for the role of prematurity and the significance of added stress in the pathogenesis of hyaline membrane disease, it seems pertinent to examine the occurrence of the disease in twins. Were prematurity alone the determinant of the likelihood of developing the disease, one would expect the disease to occur in both twins. If perinatal stress were a significant factor in the pathogenesis of the disease, then Twin B should have it more commonly than Twin A. A greater incidence in Twin B has been cited by several investigators in reviews of their experience with the disease. Crosse See Table in the PDF file. found hyaline membranes in 8.4% of liveborn autopsied twins delivered first, and in 15.1% of the second born.1

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