THE RENAL FACTOR IN ARTERIAL HYPERTENSION WITH COARCTATION OF THE AORTA 1

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Abstract
Partial occlusion of the aorta in rats produces hypertension (cardiac hypertrophy) only when there is living renal tissue distal to the occlusion. The kidney is apparently unique in the pathogenesis of hypertension when an organ''s artery is partially occluded. Consideration of the hydrodynamics in coarctation of the aorta indicates that the high arterial pressure in the upper part of the body in that condition is not directly due to mechanical obstruction of the aorta but rather to widespread increased peripheral resistance in the small vessels of the upper part of the body. The cause of that increased resistance may be the interference with renal blood supply which is secondary to stenosis of the isthmus of the aorta.