Studies on Experimental Influenza in Mice

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Abstract
Virus growth in organs of mice after intranasal, inracerebral and intraperitoneal inoculations of influenza virus, PR8 was studied. Even the inoculum was given from unnatural routees, the highest growth was obtained in lung among the organs tested. The mouse here used was three-weeks-old one and the virus titer in lung after intraperitoneal and intracerebral inoculations of large dosis of virus was just comparable to that obtained after inhalation of the small inoculum. In spite of such good growth, mice did not succumb after these unnatural inoculations, and sudden fall of virus titer in the lung was remarkable on the fifth day. Early and high antibody rise at these occasions was correlated to this sudden fall of virus titer. The significance of hemagglutinisns with low infectivity detectable in kidney and liver particularly at the time of intraperitoneal or intracerebral inculations was discussed.

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