Inhibition by Dipyridamole of Arterial Thrombosis in Rats
- 1 January 1968
- journal article
- schattauer gmbh
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 20 (01/02) , 257-266
- https://doi.org/10.1055/s-0038-1651265
Abstract
Thrombi in mesenteric arteries of the rat were produced by electric means. The effectiveness of 4 agents – heparin, aspirin, warfarin, and dipyridamole – in modifying arterial thrombosis was examined with this model. Heparin and aspirin had equivocal beneficial effects. Warfarin had a deleterious effect: the duration of complete occlusion was prolonged. In striking contrast, dipyridamole induced a marked shortening in the duration of complete thrombotic occlusion. On reinjection of the drug, occlusion was almost completely suppressed.Keywords
Funding Information
- National Institutes of Health (Research Grant HE-9863)
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