Studies on the Selection of New Matrices for Ultraviolet Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry
- 1 January 1996
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 10 (15) , 1927-1933
- https://doi.org/10.1002/(sici)1097-0231(199612)10:15<1927::aid-rcm709>3.0.co;2-v
Abstract
A new group of compounds has been successfully tested as matrices for ultraviolet matrix-assisted laser desorption/ionization mass spectrometry (UV-MALDI MS). Several new matrices for UV-MALDI MS have been found by choosing, as potential matrices, compounds that perform an intramolecular proton transfer along an intramolecular H-bond under UV irradiation. Compounds of this type are, for example, salicylamide, salicylanilide, several ortho-hydroxyacetophenones and ortho-hydroxybenzophenones. The matrix activity of these compounds is compared to the corresponding meta- and para-isomers and to the matrix activity of such well known matrices as 2,5-dihydroxybenzoic acid and 2,4,6-trihydroxyacetophenone. It was found that meta- and para-substituted hydroxycarbonyl compounds show either a significantly lower or no matrix activity compared with the ortho isomers.Keywords
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