Polymer supported synthesis of oligonucleotides by a phosphotriester method
Open Access
- 1 January 1982
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 10 (20) , 6295-6303
- https://doi.org/10.1093/nar/10.20.6295
Abstract
A new polymer supported synthesis of deoxyribooligonucleotides which can be adapted to automation is described. The method is based on the elongation of an oligomer chain in the 5′- to 3′-end direction using the modified phosphotriester chemistry. The approach is exemplified by the synthesis of a nonanucleotide d(TTCGTCTTG).Keywords
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