A SLIDE TEST MODIFICATION OF THE HEMAGGLUTINATION TEST FOR ANTIBODIES AGAINST TUBERCLE BACILLI

Publisher Website
Google Scholar
Abstract
The method of Middlebrook and Dubos demonstrating specific serum agglutination of (sheep) erythrocytes sensitized with extracts of tubercle bacilli has the disadvantage of necessitating absorption of anti-sheep cell agglutinins. This disadvantage can be avoided by using group O, RH-negative human cells. The mechanism of the method is similar to that of the Coomb''s test for RH antibodies. It amounts to adsorption of either antigen or antibody onto erythrocytes and then treatment with corresponding antibody or antigen. And since the Coomb''s test has been reduced to a slide technic, the same routine can be (and has been) successfully adapted to the hemagglutination test for antibodies against tubercle bacilli.

This publication has 2 references indexed in Scilit: