Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects
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- 24 July 2009
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 325 (5939) , 490-493
- https://doi.org/10.1126/science.1175055
Abstract
Keeping Calm: Benzodiazepines are the most prescribed anxiolytics and are used by a broad population. However, benzodiazepines can cause unwanted side effects, including sedation, development of tolerance, and withdrawal symptoms after long-term administration.Rupprechtet al.(p.490; published online 18 June) now find that a translocator protein (18-kD) ligand, XBD173, is a fast-acting anxiolytic agent, both in animals and humans, which lacks the unwanted side effects of benzodiazepines and provides a promising target for novel clinically effective anxiolytic drugs.Keywords
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