Prenatal diagnosis and linkage disequilibrium with cystic fibrosis for markers surrounding D7S8
- 31 July 1990
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 85 (3) , 275-278
- https://doi.org/10.1007/bf00206745
Abstract
Three polymorphic DNA markers surrounding the D7S8 locus were tested for their usefulness in the diagnosis of cystic fibrosis (CF) by linkage analysis. The markers correspond to the loci D7S424 and D7S426. These polymorphisms were studied by centers in the U.S., the United Kingdom, the Netherlands, and Italy, using samples from populations throughout Europe and North America. The additional information provided by these probes increased the heterogeneity of the region from 50% to 58% and was essential for a completely informative diagnosis in one family. A very high degree of linkage disequilibrium was found between these markers, which span a distance of approximately 250kb. In addition, linkage disequilibrium with CF was noted. Significant heterogeneity of linkage disequilibrium was found among the populations, both for the marker-marker pairs and between the markers and CF.This publication has 22 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Identification of the Cystic Fibrosis Gene: Chromosome Walking and JumpingScience, 1989
- Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNAScience, 1989
- A DNA Segment Encoding Two Genes Very Tightly Linked to Huntington's DiseaseScience, 1987
- Linkage relationships and allelic associations of the cystic fibrosis locus and four marker lociHuman Genetics, 1987
- FIRST-TRIMESTER PRENATAL DIAGNOSIS OF CYSTIC FIBROSIS WITH LINKED DNA PROBESThe Lancet, 1986
- Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA MarkerScience, 1985
- Localization of cystic fibrosis locus to human chromosome 7cen–q22Nature, 1985
- A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7Nature, 1985
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1984