The Relationship between Amyloid and Tau
- 1 January 2003
- journal article
- review article
- Published by Springer Nature in Journal of Molecular Neuroscience
- Vol. 20 (2) , 203-206
- https://doi.org/10.1385/jmn:20:2:203
Abstract
Based on genetic findings, the relationship between the APP/Aβ and tau/tangle pathologies are discussed. It is argued that APP/Aβ is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Aβ can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.Keywords
This publication has 17 references indexed in Scilit:
- Susceptibility Locus for Alzheimer's Disease on Chromosome 10Science, 2000
- Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin MiceThe Journal of cell biology, 2000
- Pathways to Primary Neurodegenerative DiseaseMayo Clinic Proceedings, 1999
- A stop-codon mutation in the BRI gene associated with familial British dementiaNature, 1999
- Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein GenesPublished by Elsevier ,1998
- Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol HomeostasisScience, 1997
- Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseNature, 1995
- Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor proteinNature, 1995
- Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family memberPublished by Elsevier ,1992
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseNature, 1991