The Effect of Hematocrit on Cerebral Blood Flow Velocity in Neonates and Infants Undergoing Deep Hypothermic Cardiopulmonary Bypass

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Abstract
Varying degrees of hemodilution are used during deep hypothermic cardiopulmonary bypass.However, the optimal hematocrit (Hct) level to ensure adequate oxygen delivery without impairing microcirculatory flow is not known. In this prospective, randomized study, cerebral blood flow velocity in the middle cerebral artery was measured using transcranial Doppler sonography in 35 neonates and infants undergoing surgery with deep hypothermic cardiopulmonary bypass. Patients were randomized to low Hct (aiming for 20%) or high Hct (aiming for 30%) during cooling on cardiopulmonary bypass (CPB). Systolic (Vs), mean (Vm), and diastolic (Vd) cerebral blood flow velocity, as well as pulsatility index (PI = [Vs - Vd]/Vm) and resistance index (RI = [Vs - Vd]/Vs) were recorded at six time points: postinduction, at cannulation, after 10 min cooling on CPB, rewarmed to 35[degree sign]C on CPB, immediately off CPB, and at skin closure. Vm was significantly lower in the high Hct group compared with that in the low Hct group during cooling (P (Anesth Analg 1999;89:322-7)

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