EFFECTS OF 2, 4-DINITROPHENOL ON THE EARLY DEVELOPMENT OF THE TELEOST, ORYZIAS LATIPES

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Abstract
Exposure was begun at the stages of early and late cleavage, closure of the blasto-pore and optic vesicle. Sensitivity to the drug decreases with age and differentiation while the general effect is cumulative and proportional to the cone, and length of exposure. In addition to inhibitory and retardative effects, other developmental abnormalities include those of the heart, blood vessels, myotomes, nervous system, body size, etc. The most significant results appear at cones, from 1:40,000 to 1:200,000. There is no developmental stimulation, gastrulation is either inhibited or retarded and no special type of teratological embryo is produced.