The vitamin E activity of α-tocopherylquinone and α-tocopherylhydroquinone in the rat

Open Access
Publisher Website
Google Scholar
Abstract
[alpha]-Tocopherylquinone and [alpha]-tocopherylhydroquinone were examined for activity in the gestation-resorption test in the rat and found to have about 0.4 and 0.6% respectively of the potency of D-[alpha]-tocopheryl acetate. This amount is more than can be accounted for by traces of [alpha]-tocopherol that might have been present in the products. a-Tocopherylquinone, given orally to rats, significantly inhibited the production of malonaldehyde by liver homogenates in vitro. It had about 5-10% of the activity of D-[alpha]-tocopheryl acetate. a-Tocopherylquinone inhibited malonaldehyde formation in vitro in liver homogenates of vitamin E-deficient rats, having 45% of the activity of D-[alpha]-tocopheroh Reduced nicotinamide-adenine dinucleotide-linked reductase activity for tocopherylquinone was found in rat liver and adrenal and in chick liver, kidney and breast muscle.

This publication has 31 references indexed in Scilit: