Experimental infection of Getah virus in swine.

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Abstract
Pigs 5 months old and piglets 9 days old were inoculated intracerebrally, intravenously, or subcutaneously with Getah virus. All the inoculated animals remained unchanged clinically, but were affected with viremia. In them, hemagglutination inhibiting (HI) antibody began to be detected one week after inoculation and reached its highest titer 2 weeks after inoculation. When five pregnant sows were inoculated subcutaneously with strain 2078, all of them suffered from viremia and produced HI antibody. Four of them were subjected to laparotomy some time between 11 and 28 days after inoculation and examined for fetuses harbored. In sows which inoculated in the early stage of pregnancy, dead fetuses were found and the virus was recovered from the placenta, amniotic fluid, and fetal body. The results mentioned above suggested that swine is susceptible to Getah virus and the possibility that infection with Getah virus might be one of the causes of reproductive disorders in pregnant sows.

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