Highly Efficient Asymmetric Hydrogenation of Activated and Unactivated Ketones Catalyzed by Rhodium(I) Aminophosphine- and Amidophosphine-Phosphinite Complexes. Beneficial Effect of the Non Chiral Ligand
- 1 April 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (04) , 358-360
- https://doi.org/10.1055/s-1995-4959
Abstract
The chiral ligands aminophosphine- and amidophosphine-phosphinites (4-8), when associated to neutral rhodium precursors, are efficient ligands for the asymmetric hydrogenation of ketopantolactone 1, N-benzylphenylglyoxamide 2, and 2-aminoacetophenone 3. Under mild conditions the hydrogenations led to high enantiomeric excesses (67-98.7%). The effect of the non chiral ligand (Cl, I, CH3CO2, CF3CO2, and C3F7CO2) is presented.Keywords
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