Selective cleavage of the amido linkage of glucopyranosylamine derivatives by ion-exchange resin treatment.

1 January 1984

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 32 (9) , 3698-3701
https://doi.org/10.1248/cpb.32.3698

Abstract

The amido linkage of various glycosylamine derivatives, N-(L-γ-glutamyl)-α-, and-β-D-glucopyranosylamine, N-(L-β-aspartyl)-α-and-β-D-glucopyranosylamine and N-glycyl-α-D-glucopyranosylamine, can be cleaved by Amberlite IRA-410 (OH^-), as evidenced by the appearance of the aglycone amino acids and the disappearance of the starting amide.

Keywords

AMINO ACIDS
TREATMENT
GLUCOPYRANOSYLAMINE
EXCHANGE RESIN
AMIDO LINKAGE
GLYCOSYLAMINE DERIVATIVES
VARIOUS GLYCOSYLAMINE

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