Ketosis in the rat on a fat diet

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Abstract
The course of ketosis has been investigated in rats fasted for 24 hours and fed subsequently on various levels of butter fat. Ketonemia persisted under all diets which were deficient in calories but was reduced markedly, and was sometimes abolished, when the calorie requirement was met entirely from exogenous fat. The amount of liver fat and glycogen increased in proportion to the quantity of fat fed. A correlation existed between the amount of liver fat and the quantity of fat present in the depots. Appreciable quantities of liver glycogen were found during ketosis. A critical amount of liver glycogen is thought not to initiate in itself the reduction in ketosis described. A non-glycogenolytic, ketogenic, fat-mobilizing hormone (or hormones) is probably secreted as a response to the stimulus of calorie deficiency in the tissues. The use of ketonuria to estimate the degree of ketosis is criticized.