The complete primary structure of Cw*1701 reveals a highly divergent HLA class I molecule
- 1 March 1997
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 49 (3) , 267-270
- https://doi.org/10.1111/j.1399-0039.1997.tb02749.x
Abstract
Genotyping of the HLA-C locus by PCR-SSP has previously shown 100% association of B41 and B42 with a new allelic variant. Partial sequencing studies (exons 2-4) demonstrated that this PCR-SSP variant corresponded to the new allele Cw*1701. In this study we have characterized the whole coding region of Cw*1701 from a Bubi individual of Equatorial Guinea. Our results partially confirm the previously reported sequence and reveal that Cw*1701 has many new polymorphisms at several exons, including a 18-bp insertion in exon 5. Cw*1701 is thus a most unusual HLA-C molecule defining a third allelic lineage of this locus.Keywords
This publication has 11 references indexed in Scilit:
- Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706Tissue Antigens, 1996
- High resolution HLA-C typing by PCR-SSP: identification of allelic frequencies and linkage disequilibria in 604 unrelated random UK Caucasoids and a comparison with serologyTissue Antigens, 1996
- Brief communication HLA-C genotyping in the Japanese population by the PCR-SSP methodTissue Antigens, 1996
- O41: Promoter polymorphism of the HLA-C locusHuman Immunology, 1996
- HLA Class I nucleotide sequences, 1995Tissue Antigens, 1995
- Nomenclature for factors of the HLA system. 1995Tissue Antigens, 1995
- ANTIGENIC CHARACTERISTICS AND cDNA SEQUENCES OF HLA‐B73International Journal of Immunogenetics, 1995
- The HLA‐B73 antigen has a most unusual structure that defines a second lineage of HLA‐B allelesTissue Antigens, 1994
- Rapid DNA typing for HLA-C using sequence-specific primers (PCR-SSP): Identification of serological and non-serologically defined HLA-C alleles including several new allelesTissue Antigens, 1994
- Molecular cloning and polymerase chain reaction-sequence-specific oligonucleotide detection of the allele encoding the novel allospecificity HLA-Cw6.2 (Cw∗1502) in Spanish gypsiesHuman Immunology, 1993