Esterification of Amino Acids as Their 2,2-Bis(ethoxy-carbonyl)vinyl Derivatives
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (07) , 544-547
- https://doi.org/10.1055/s-1989-27312
Abstract
A method to protect the amino group of the amino acids using diethyl (ethoxymethylene)malonate is described. The resulting derivatives are easily esterified with different alkylation agents. Elimination of the N-protecting group with bromine in chloroform affords the hydrobromides of the amino acid esters.Keywords
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