Synthesis of a Difluorophosphonate Analog of the Oxathiolanyl Nucleoside (−)-β-L-(2R,5S)-1,3-Oxathianyl-5-fluorocytosine (FTC)
- 1 October 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 14 (8) , 1803-1809
- https://doi.org/10.1080/15257779508009758
Abstract
A difluorophosphonate analog of (−)-β-L-(2R,5S)-l,3-oxathianyl-5-fluorocytosine (FTC) was prepared as part of an effort to probe the possibility of obviating the need for endogenous kinases in the activation of nucleosides as potential therapeutic agents.Keywords
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