Nutritional Deficiency and Infection: I. Influence of Riboflavin or Thiamin Deficiency on Fatal Experimental Pneumococcal Infection in White Mice

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Abstract
Mice fed syn-thetic diets that were deficient in either ribofiavin or thiamin chloride were more susceptible to a fatal infection with pneumococci, type I, when inoculated by the intranasal route than were those receiving adequate amounts of these vitamins. That the increased susceptibility to fatal infection among the riboflavin-deficient mice was not due to simple malnutrition was shown by paired feeding experiments on litter mates. The daily oral or subcut. adm. of 5-10 times the amt. of ribofiavin or thiamin chloride in the control diet, to deficient mice, beginning at the time of inoculation with pneumococci, did not reduce the number of mice dying from the infection.

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