A Rapid and Sensitive Assay for the Determination of Paraquat in Plasma by Gas-Liquid Chromatography

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Abstract
A method for the determination of paraquat in plasma which involves a protein precipitation using trichloroacetic acid, followed by a reduction of the herbicide to ether extractable compounds and subsequent gas chromatographic quantitation is described. Ethyl viologen used as an internal standard has been demonstrated to behave similarly to paraquat during the entire course of sample preparation prior to gas chromatography. Paraquat levels as low as 0.030 mg per liter can be assayed.