The role of hepatitis E virus in acute sporadic non-A, non-B hepatitis
- 1 November 1994
- journal article
- Published by Springer Nature in Infection
- Vol. 22 (6) , 407-410
- https://doi.org/10.1007/bf01715498
Abstract
Hepatitis E virus (HEV) is the cause of enterically transmitted non-A, non-B (NANB) hepatitis. Water-borne epidemics have been reported in many developing countries primarily affecting young and middle-aged adults. To determine the role of HEV in acute sporadic NANB hepatitis, we have studied the profiles of anti-HEV IgG in the sera of patients previously diagnosed for NANB hepatitis. We tested the sera of 53 patients with acute NANB hepatitis and 100 healthy people as a control group for anti-HEV IgG. Thirty-nine of the 53 patients (73.3%) and none of the control group were positive for HEV infection, according to results shown by ELISA. This result suggests that HEV is a common cause of acute sporadic NANB hepatitis in Turkey. Further studies are needed in the other regions to determine the true prevalence of HEV infection in Turkey. Das Hepatitis E Virus (HEV) ist der Erreger der enteral übertragenen Non-A, Non-B (NANB)-Hepatitis. Epidemien durch verseuchtes Wasser wurden aus vielen Entwicklungsländern berichtet, sie betrafen vor allem Jugendliche und Erwachsene mittleren Alters. Um die Rolle des HEV bei der akuten NANB-Hepatitis zu bestimmen, haben wir die anti-HEV IgG Profile der Seren in früher als NANB-Hepatitis diagnostizierten Fällen bestimmt. Wir testeten die Seren von 53 Patienten mit akuter NANB-Hepatitis und von 100 gesunden Kontrollpersonen auf anti-HEV IgG. Eine HEV-Infektion wurde nach den Ergebnissen des ELISA bei 39 der 53 Patienten (73,3%), aber bei keiner Person der Kontrollgruppe festgestellt. Die Ergebnisse lassen annehmen, daß HEV eine häufige Ursache der sporadischen NANB-Hepatitis in der Türkei ist. Weitere Studien in anderen Regionen sind erforderlich, um die wirkliche Prävalenz der HEV-Infektion in der Türkei zu bestimmen.Keywords
This publication has 36 references indexed in Scilit:
- Prevalence of antibody to hepatitis a virus among children in Trabzon, TurkeyInfection, 1993
- Detection of long-lasting antibody to hepatitis E virus in a US traveller to PakistanThe Lancet, 1992
- Acute Sporadic Hepatitis E in Sudanese Children: Analysis Based on a New Western Blot AssayThe Journal of Infectious Diseases, 1992
- Serologic identification of hepatitis E virus infections in epidemic and endemic settingsJournal of Medical Virology, 1992
- Association of hepatitis E virus with an outbreak of hepatitis in Pakistan: Serologic responses and pattern of virus excretionJournal of Medical Virology, 1992
- Outbreak of acute hepatitis E virus infection among military personnel in northern EthiopiaJournal of Medical Virology, 1991
- Virus‐like particles in the liver of a patient with fulminant hepatitis and antibody to hepatitis E virusJournal of Medical Virology, 1990
- Hepatitis E virus.BMJ, 1990
- Epidemic non‐A, non‐B viral hepatitis in algeria: Strong evidence for its spreading by waterJournal of Medical Virology, 1985
- Epidemic non-A, non-B hepatitis in Nepal. Recovery of a possible etiologic agent and transmission studies in marmosetsJAMA, 1984