PSEUDOREFLEX FROM ENDPLATE AND SENSORY NERVE ENDING

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Abstract
In the single nerve fiber-muscle prepn. treated with guanidine, a single centrifugal impulse sent through the nerve fiber evoked a repetitive series of centripetal impulses from the muscle. Sometimes a similar burst of discharges appeared spontaneously. Simultaneous records of nerve impulses, endplate potentials, (e.p.p.) and muscle action potentials showed that each backfired nerve impulse always preceded the muscle action potential, but was elicited at the critical value of the e.p.p. Similar recurrent discharges were observed in the sensory fiber-skin prepn. soaked in guanidine-Ringer soln. The guanidine-treated skin prepn. responded to a mechanical stimulus with more impulses than untreated and also often showed a spontaneous discharge. Repetitive stimulation of the central portion of the nerve in the nerve fiber-muscle prepn. produced a single recurrent discharge until the interval between stimulation was shortened to about 20 msec, while in the sensory nerve fiber-skin prepn. even the repetitive shock of far smaller interval caused the backfiring of impulses. Thus it is concluded that the site at which backfiring of impulses is produced is theendplate and sensory nerve fiber ending, respectively, and that the e.p.p. and the depolarization of the sensory nerve ending might have played an important role in these pseudoreflexes.

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