Active state properties ofdenervated and immobilized muscle

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Abstract
Possible roles of neurotrophic mechanisms and muscle activity in the contractile abnormalities of muscular dystrophy were studied by comparing human dystrophic muscle to denervated and immobilized [rabbit] muscle. As evident in denervated muscle from the decreased acceleration of twitch development (decreased active state intensity of shortening) and isoproterenol-induced decrease of twitch with shortened decay of the active state, part of the abnormality in the subcellular Ca transport system in dystrophic muscle seems influenced by disordered neural regulation. Other active state abnormalities relating to activation processes and contractile proteins in dystrophic muscle were also demonstrated in both denervated and immobilized muscle, with some being more marked in immobilized muscle. A neurogenic hypothesis cannot entirely explain the pathogenesis of progressive muscular dystrophy.