CD4+ and CD56+ acute monoblastic leukemia

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Abstract
We report here a patient with acute monoblastic leukemia whose leukemia cells had CD4 (T4) and CD56 (NKH‐1) antigens, in addition to CD36 (OKM5) antigen. The leukemia cells did not have NK or ADCC activities. They showed no rearrangements of immunoglobulin heavy (IgH) chain and T cell receptor (TCR)‐beta chain genes, indicating that the leukemia cells were nonlymphoid. The presence of this case suggests that leukemia cells could be orginated from monocytes with NK‐associated antigen without IgH or TCR rearrangements.