Nitazoxanide as a Broad‐Spectrum Antiparasitic Agent

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Abstract
To the Editor—In a randomized, double-blind, placebo-controlled study of nitazoxanide, Rossignol et al. [1] reported excellent therapeutic response in patients with diarrhea caused by Giardia intestinalis and Entamoeba histolytica and/or Entamoeba dispar infection. Earlier open-label clinical investigations of therapeutic response to nitazoxanide in 125 patients with Fasciola hepatica infection, with parasitologic examination of stool samples 30 days after initiation of treatment, pointed toward its safety and efficacy [2]. Furthermore, nitazoxanide has been effective during experimental investigations of treatment of antibiotic-induced Clostridium difficile intestinal disease in hamsters. Intragastric treatment with nitazoxanide for 6 days, when followed by an inoculation of toxigenic C. difficile, resulted in survival of the animals during a 15-day observation period. Necropsy disclosed no signs of toxicity or of C. difficile intestinal disease [3].

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