Trouble on the pitch: are professional football players at increased risk of developing amyotrophic lateral sclerosis?
Open Access
- 5 January 2005
- journal article
- editorial
- Published by Oxford University Press (OUP) in Brain
- Vol. 128 (3) , 451-453
- https://doi.org/10.1093/brain/awh426
Abstract
With the exception of some rare familial forms of the disease, the cause of amyotrophic lateral sclerosis (ALS; motor neuron disease) is unknown (Bruijn et al., 2004). Although 90–95% of ALS cases are apparently sporadic, SOD1 gene mutations with low penetrance (Cudkowicz et al., 1997; Anderson et al., 1997; Shaw et al., 1998; Al-Chalabi et al., 1999; Orrell et al., 1999; Andersen et al., 2003; Majoor-Krakauer et al., 2003; Nogales-Gadea et al., 2004) and other gene variants or mutations may contribute to the population risk (Al-Chalabi et al., 1999; Mitchell, 2000; Lambrechts et al., 2003; Majoor-Krakauer et al., 2003).Keywords
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