POSTBURN IMMUNOSUPPRESSION IN AN ANIMAL-MODEL .2. RESTORATION OF CELL-MEDIATED-IMMUNITY BY IMMUNOMODULATING DRUGS
- 1 January 1984
- journal article
- research article
- Vol. 95 (3) , 290-296
Abstract
A model of full-thickness burn injury in the mouse was used and cell-mediated immunity (CMI) were quantitated by measuring the degree of sensitization to the contact antigen, 2,4-dinitrofluorobenzene (DNFB). CMI in the burned mouse is severely suppressed. Using this immunosuppression model, CMI was significantly restored by treating animals following the burn injury either with ibuprofen or indomethacin (nonsteroidal) anti-inflammatory drugs) or with the cytotoxic alkylating agent cyclophosphamide. These drugs probably restore CMI by inhibiting generation of suppressor T lymphocytes in the burned host.This publication has 37 references indexed in Scilit:
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