IMMUNOSUPPRESSION BY THORACIC DUCT FILTRATION

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Abstract
SUMMARY Closed circuit extracorporeal filtration of bovine thoracic duct lymph produced an extended period of immunosuppression in the absence of supportive chemotherapy. Filtration for 11 days produced a reduction in the lymph cell count of over 85%. This decrease in cell count was accompanied by the ablation of delayed-type hypersensitivity and primary antibody response. Prolonged filtration produced leukopenia in the peripheral blood. All other measured blood parameters remained normal as did serum and lymph immunoelectrophoresis patterns. Histological studies revealed lymphoid tissue void of small lymphocytes. After filtration, the period of repopulation and immunosuppression was quite long in relation to the days of filtration needed to produce this state

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