Pharmacokinetics of Tenoxicam after oral administration in healthy human subjects of various single doses

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Abstract
Single oral dose pharmacokinetics of tenoxicam in the dose range intended for therapeutic application of the drug have been defined in healthy human subjects. Twelve male volunteers were given, in random fashion, oral administration of 10, 20 or 40 mg of tenoxicam. Plasma drug levels were determined by a standard HPLC method with U.V. detection. Model-independent analysis showed the clearance, elimination half-life and apparent volume of distribution to be independent of dose with mean values of 0.096 L/h, 76 h and 9.2 L respectively. Interindividual variation was six-fold and individual variation less than two-fold. Similar values for kinetic parameters were obtained by model-dependent methods. The pharmacokinetics of oral tenoxicam were linear in the 10–40 mg dose range and the single dose data predict five-fold accumulation for once daily administration.