Dexamethasone Fails to Suppress β-Endorphin Plasma Concentrations in Humans and Rhesus Monkeys
- 15 August 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4458) , 827-828
- https://doi.org/10.1126/science.6250217
Abstract
In humans and rhesus monkeys, dexamethasone decreased concentrations of plasma cortisol but did not alter circulating β-endorphin immunoreactivity. Contrary to current theory suggesting that pituitary β-endorphin and adrenocorticotropic hormone are controlled by identical regulatory mechanisms for synthesis and release, our evidence suggests that in higher primates the established glucocorticoid feedback mechanism for the adrenocorticotropic hormone-cortisol system does not regulate β-endorphin secretion in the same way.Keywords
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