TREATMENT OF ULCERATIVE COLITIS

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Abstract
The long-term management of patients with chronic ulcerative colitis is difficult, and the usual therapeutic regimens are often unrewarding. For many years various etiological agents have been postulated, including bacteria,1 viruses,2 enzymes such as lysozyme,3 food allergies,4 and vitamin deficiencies.5 Eventually the evidence on all of these has been inadequate.6 The present-day chemotherapeutic agents and antibiotics are apparently useful only in some acute febrile exacerbations of the disease.7 Their failure to basically alter the course of the disorder indicates that microorganisms are probably not involved primarily. Murray8 noted that the onset and each exacerbation of the disease occurred during periods of stressful life situations. Many investigators have corroborated and elaborated his findings.9 Experimental studies have demonstrated the relationship between life stress and ulceration of the colonic mucosa in man.10 This report is based on the study of 19 unselected persons